![]() Amanita phalloides deathcap mushroom toxicity : Silibinin.intralipid may decrease the effectiveness of lipid soluble therapeutic agents) Interference with other therapies (e.g.digoxin levels increase after digibind intralipid may cause spurious biochemistry results) interference with laboratory assays (e.g.NAC may worsen hypotension in a mixed paracetamol / cardiotoxic overdose) unanticipated effects in mixed overdoses (e.g.benzodiazepine withdrawal from flumazenil, sympathetic crisis and pulmonary edema from naloxone) NAC, anaphylactoid reaction to vitamin K, allergy to antivenom) resuscitation, supportive care and monitoring) distraction from other management priorities (e.g.The harms are often well quantified and are an important determinant of the threshold for antidote use. Many antidotes have an excellent safety profile (e.g. ![]() some antidotes have fixed doses to ensure complete receptor/ pathway blockage (e.g.repeated naloxone doses or an infusion may be required with long-acting opioids) ![]()
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